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Package cost

IVF €4300

Egg donation €3750

Basic information about IVF treatment at S.I.S.Me.R..

Maximum age of the woman: 50
Single woman: not allowed
Lesbian couples: not allowed
HIV positive patients (female): not allowed
HIV positive patients (male): not allowed
HCV/HBV positive patients (female): allowed
HCV/HBV positive patients (male): allowed

S.I.S.Me.R. clinic was established in 1994 and employs professionalists who were previously operating at a different clinic since 1985. In 2020, the clinic performed in total 505 treatments of which 16.2% were egg donation cycles, 5% were IVF cycles with own eggs and 26.5% were IVF + ICSI.

The clinic is located in an own 4-floor building with an operating theatre, embryology lab, and the ward on the ground floor, 5 consultation rooms on the first floor, an andrology lab, molecular biology lab, and administrative offices on the second floor and a meeting room (capacity for up to 60 people) on the third floor.

There are 3 laboratories, one operating theatre (picture below), and 2 recovery rooms for patients (one with 2 beds ensuite, and one with 6 beds + bathroom).

SISMER operating theatre

The Medical Director is Dr. Daniele Barnabè who has a University Degree in Medicine and Surgery (1980, Bologna University) and is Specialized in Obstetrics and Gynecology (1984, Bologna University) and has Expertise in Quality Management. The Scientific Director is Dr. Luca Gianaroli, whose professional expertise in the field of Medically Assisted Reproduction is acknowledged nationally and internationally. He is a pioneer of PGT and a Past Chairman of the European Society of Human Reproduction and Embryology.

At the clinic, there are four doctors (excluding the Medical Director) and seven embryologists/biologists, one with 30 years of experience. The laboratory director, Dr. Maria Cristina Magli is an ESHRE Certified Senior Embryologist and the current chairman of ESHRE. All staff speaks English fluently.

S.I.S.Me.R. holds ISO 9001:2015 and has been certified since 1998 and is the first certified IVF Centre in Italy. It is also a Licensed Center in compliance with the Italian legislation.

S.I.S.Me.R. Fertility Treatments

SISMeR is a licensed 3rd level MAP Centre which means that the clinic is able to provide all MAP techniques permitted by Italian law, i.e.:

  • IUI
  • Egg donation
  • Donor sperm
  • PGT
  • Embryo/egg/sperm freezing
  • Blastocoel fluid biopsy for PGT
  • Testicular needle biopsy
  • MESA
  • TESE
  • MicroTESE.

These treatments are available at S.I.S.Me.R. for female patients up to the age of 50. According to Italian law, single women and same-sex couples do not have access to assisted reproduction treatments and surrogacy. Sex selection is not allowed. Preimplantation Genetic Screening (PGT-A) is permitted and recommended for the purpose of screening for abnormalities related to maternal age or in case of recurrent miscarriages or previous IVF failures. Preimplantation Genetic Testing for Monogenic diseases (PGT-M) and Translocations (PGT-SR) is allowed for genetic diseases (including sex-related diseases) or translocations as long as they are certified by a specialist.

To learn more about PGT and personalized IVF, watch the #IVFWEBINARS with dr. Luca Gianaroli from S.I.S.Me.R. – “Preimplantation genetic testing (PGT) – for whom and how does it help?” and “Personalization of (IVF) ART treatments“.

Online consultations are available and the preliminary phase of the treatment (monitoring) can be done in your country prior to your arrival in Bologna, in order to minimise the length of stay. Contact with the medical and paramedical staff is guaranteed by phone and e-mail, also through our network of partners (depending on availability). The cost of the first consultation is €202 and it can be done in person or by video call.

S.I.S.Me.R. special services for UK patients

For couples based in the United Kingdom, special services have been developed together with TheFertilityPharmacy – pre-visit blood tests and scans, home delivery of medication and a unique Nurse at Home service where the nurses can help you with your injections or infusions. This will prepare you before coming to Bologna for the procedure. Once back home, you will be supported by The Fertility Pharmacy step by step.

Need to find out more about a particular treatment? Contact S.I.S.Me.R.

S.I.S.Me.R. Price List 2021

IVF with own eggs

The cost of an IVF with own eggs program is €4,300 and it includes:

  • hormonal assays,
  • ultrasound monitoring,
  • oocyte retrieval,
  • in vitro fertilization,
  • embryo culture,
  • embryo transfer,
  • cryopreservation of surplus embryos.

Egg Donation Program

Depending on the egg donation program selected by the couple, the price ranges between €3,750-6,900. The programs include:

  • egg donor selection and treatment,
  • matching,
  • psychological consultation,
  • oocyte insemination,
  • ICSI,
  • extended culture to blastocyst,
  • embryo/egg vitrification,
  • one embryo transfer.

 The cost of sperm freezing is €302 + a subsequent yearly fee for storage. The clinic offers an egg sharing program as well. If you decide to go back to the clinic for a frozen embryo transfer, the cost is €1,800.

Egg donation in Italy is strictly regulated according to EU directives and national regulations. For donors, egg donation is anonymous and altruistic which means that compensation/reimbursement is strictly forbidden. All donors must undergo physical, genetic and psychological assessment in order to be certified as eligible to donate. Phenotype matching is mandatory in Italy and it is always performed so you can rest assured that there will be a resemblance in terms of hair or eye colour.
Neither donors nor recipients are allowed to know their respective identities. Children born following gamete donation in Italy are not entitled to receive identifying information about the donor.
Gamete donation can only be performed upon medical indications.

Use our IVF Cost Calculator to help understand costs.

If you have any questions about treatments, Contact S.I.S.Me.R.

S.I.S.Me.R. Success Rates 2020

The egg donation clinical pregnancy rate per embryo transfer was 27.7%.

The clinical pregnancy success rate for IVF with own eggs per embryo transfer in 2020 was 26.8% and the success rates per age were as follows:

  • women under 35 years old: 38.5%
  • women 35-40 years old: 30.8%
  • women over 40 years old: 10.5%

The frozen embryo clinical pregnancy success rates were 32.2% with own gametes and 42.9% with donor eggs.

At S.I.S.Me.R., the doctors transfer an embryo on day 3 or day 5 or other depending on the type of treatment performed. Only one embryo is usually transferred (2 embryos are transferred rarely and in specific cases). The average number of embryos transferred is 1.2. This gave the multiple birth rate of 6.2% in 2020.

Need more information on IVF success rates? Contact S.I.S.Me.R.


From the staff

At SISMER we care about our patients, accompanying them during their diagnostic and therapeutic pathway and offering them top quality Reproductive Care since 1994. SISMER offers all ART treatments allowed in Italy at its headquarters in Bologna and at its associated Centers in Italy and Switzerland. A multidisciplinary team of professionals is at patients’ disposal throughout their whole journey.

SISMER cares about safety and quality. It is an ISO certified Center since 1998 and gives great importance to research and education.

SISMER Reproductive Care. A matter of Health. And Life.

Who attends?

The patients of the clinic are mostly national and the rest comes from the following countries: 0.6 % from the UK; 0.4 % from San Marino; 0.4 % from Switzerland; 0.4 % from the USA; 0.2 % from France.

Clinic Location

S.I.S.Me.R. is located within walking distance from the city centre of Bologna. From the railway station: approx. 25 min. (bus stop right outside the clinic – lines 25, 27, 32, 33), by taxi from the railway station: approx. 10 minutes. By taxi from the airport: approx. 40 min (except rush hours). There is no private parking, several car parks are available nearby. Discounted rates for S.I.S.Me.R.’s patients.

For patients and guests, S.I.S.Me.R. has made agreements with a group of selected hotels. The affiliated 4-star hotels include Grand Hotel Majestic (già Baglioni), Hotel Aemilia, Hotel Commercianti Novecento, Al Cappello Rosso, Al Cappello Rosso, Al Cappello Rosso, Hotel I Portici, Tower Hotel Bologna Best Western Plus, Hotel Corona d’Oro, Savhotel, and 3-star hotels are Blumen, Orologio and Metropolitan.

By Dorothy Walas

Basic information about treatment restrictions at S.I.S.Me.R..

Maximum age of the woman:50
Single woman: not allowed
Lesbian couples: not allowed
HIV positive patients: not allowed
HIV positive patients (male): not allowed
HCV/HBV positive patients: allowed
HCV/HBV positive patients (male): allowed

Use the form below to contact S.I.S.Me.R. if you need some more information on IVF costs, success rates, clinic experience or anything else. There's no commitment.

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