Ovarian Rejuvenation with PRP
Ovarian rejuvenation is an emerging treatment designed to activate “sleeping” follicles in women with low ovarian reserve or early menopause. The main goal is to stimulate the ovaries to produce more eggs, increasing the chances of pregnancy—especially through IVF.
This approach falls under regenerative medicine, which harnesses the body’s own self-healing mechanisms. While still considered experimental, early results show promise in women who previously had very few or no viable oocytes during fertility treatment.
What Is PRP Ovarian Rejuvenation?
The most common ovarian rejuvenation method today is the intraovarian injection of Platelet-Rich Plasma (PRP). This procedure involves extracting a small amount of the patient’s own blood, processing it through a centrifugation process to isolate platelets, and injecting the growth factor–rich plasma directly into the ovaries.
Growth factors are critical for early follicular development, and injecting PRP helps boost their concentration in the ovarian environment. This can potentially “wake up” residual follicles and help produce more eggs during ovarian stimulation.
How Does Ovarian Rejuvenation Work?
Two key techniques are currently being used in ovarian rejuvenation:
- PRP Injection. The patient’s own blood is spun in a lab to isolate platelets, which are rich in growth factors. This PRP is then injected into the ovaries to stimulate follicular activity.
- Ovarian Cortex Fragmentation & Reimplantation. Known as OFFA (Ovarian Fragmentation for Follicular Activation), this method involves surgically removing and fragmenting a piece of the ovarian cortex. The tissue is then reimplanted into the ovary to stimulate residual follicles. This technique is used in select cases, especially for women with ovarian failure or early menopause.
Who Is It For?
Ovarian rejuvenation may be considered for women diagnosed with:
- Low ovarian reserve
- Early menopause
- Poor response to IVF
- Residual but inactive follicles
However, not every patient is a candidate. Contraindications include:
- Genetic causes of ovarian failure
- A single ovary
- Ovarian pathology
- Prior chemotherapy
Medical teams assess each case individually before recommending treatment.
What to Expect
This therapy is not a guarantee but has shown improved response in certain women. The goal is to retrieve even one more egg during IVF stimulation, which could make the difference in success. Some women have reported spontaneous pregnancies or increased egg yield in IVF following PRP or OFFA treatment.
Treatment planning is personalized, and procedures are carried out following scientific reviews and protocols that ensure safety and measurable improvement.
Ovarian Rejuvenation Abroad
While the treatment is available in a few countries, interest is growing in locations such as:
- North Cyprus and Greece, where reproductive clinics offer personalized therapies for low-responder patients.
- The UK and Ireland, where clinics are beginning to adopt ovarian PRP and OFFA protocols.
- Spain, where protocols for ovarian rejuvenation have been developed based on pharmacogenetic and luteal phase stimulation insights.
Top Clinics Offering Ovarian Rejuvenation in Spain
While the list evolves as more clinics adopt these techniques, the following centers are recognized for their experience and research-driven approach:
- Clinica Tambre – Madrid
- Instituto Bernabeu – Alicante
- UR Vistahermosa – Alicante
- Natuvitro – Barcelona
